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Cells in the pancreas can release glucagon, a hormone that signals the body to produce glucose from glycogen in the muscles and liver and release it into the blood. The researchers found that when the pancreas released the glucagon on a low-dose insulin and reduced insulin doses throughout the day in healthy people, that helped improve glucose control and improve glycaemia. On the other hand, insulin doses above the normal range, increased glucagon release, so those who were insulin sensitive and had low glucagon production and were fasting had worse glucose control and more than double the risk of developing diabetes. The researchers also found that in patients in the glucose-lowering phase of the fasting trial, glucagon release was low at the beginning and was suppressed during the rest of the study, so those who received insulin and had low glucagon levels were about 1 percent more likely to develop diabetes compared with people who didn't receive insulin and didn't need to cut back on insulin. The researchers didn't find any effect on blood sugar levels when patients increased their insulin dosage over a six-week period, after which glucagon released from the pancreas increased. Insulin, the hormone that makes glucose. Associated Press The researchers concluded that "insulin is essential to preventing or reversing the onset of a number of diseases, and the effect of its release on the pancreas appears to depend on the type of insulin." The researchers did not find anything different after the researchers cut back on insulin. The patients who continued to receive high insulin doses had no effect on the pancreas, the researchers wrote. The study was also limited by the small sample size. The researchers noted that the patients who received insulin and had low glucagon release had the same risk as those patients who received low glucagon. A study published this month found that fasting blood glucose has a greater impact on long-term cardiovascular disease than does insulin. A study fun